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作者:Chiara Azzi , Florian Aeschimann , Anca Neagu ...
来源:[J].eLife, 2020, Vol.9
摘要:Robust organismal development relies on temporal coordination of disparate physiological processes. In Caenorhabditis elegans , the heterochronic pathway controls a timely juvenile-to-adult (J/A) transition. This regulatory cascade of conserved proteins and small RNAs culminates ...
作者:Nora C Pyenson , Luciano A Marraffini
来源:[J].eLife, 2020, Vol.9
摘要:Type II CRISPR-Cas systems provide immunity against phages and plasmids that infect bacteria through the insertion of a short sequence from the invader’s genome, known as the ‘spacer’, into the CRISPR locus. Spacers are transcribed into guide RNAs that direct the Cas9 n...
作者:Marc J Williams , Luis Zapata , Benjamin Werner ...
来源:[J].eLife, 2020, Vol.9
摘要:The distribution of fitness effects (DFE) defines how new mutations spread through an evolving population. The ratio of non-synonymous to synonymous mutations (dN/dS) has become a popular method to detect selection in somatic cells. However the link, in somatic evolution, be...
作者:Simranjot Bawa , David S Brooks , Kathryn E Neville ...
来源:[J].eLife, 2020, Vol.9
摘要:Cell growth and/or proliferation may require the reprogramming of metabolic pathways, whereby a switch from oxidative to glycolytic metabolism diverts glycolytic intermediates towards anabolic pathways. Herein, we identify a novel role for TRIM32 in the maintenance of glycolytic ...
作者:Court Hull
来源:[J].eLife, 2020, Vol.9
摘要:While classical views of cerebellar learning have suggested that this structure predominantly operates according to an error-based supervised learning rule to refine movements, emerging evidence suggests that the cerebellum may also harness a wider range of learning rules to cont...
作者:Michael A Schelling , Dipali G Sashital
来源:[J].eLife, 2020, Vol.9
摘要:The response of bacteria to the threat posed by phages depends on their local environment.
作者:Tracey Weissgerber , Yaw Bediako , Charlotte M de Winde ...
来源:[J].eLife, 2020, Vol.9
摘要:The need to protect public health during the current COVID-19 pandemic has necessitated conference cancellations on an unprecedented scale. As the scientific community adapts to new working conditions, it is important to recognize that some of our actions may disproportionately a...
作者:Michael B Eisen , Anna Akhmanova , Timothy E Behrens ...
来源:[J].eLife, 2020, Vol.9
摘要:eLife is making changes to its policies on peer review in response to the impact of COVID-19 on the scientific community.
作者:Charles C Roseman
来源:[J].eLife, 2020, Vol.9
摘要:Experiments on mice have shown that developmental processes are influencing the generation of phenotypic variation in a way that shapes evolution.
作者:Judit García-González , Alistair J Brock , Matthew O Parker ...
来源:[J].eLife, 2020, Vol.9
摘要:To facilitate smoking genetics research we determined whether a screen of mutagenized zebrafish for nicotine preference could predict loci affecting smoking behaviour. From 30 screened F3 sibling groups, where each was derived from an individual ethyl-nitrosurea mutage...

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