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作者:Ruifang Li , Zhengwei Liu , Weibing Dong ...
来源:[J].Biochemical Journal(IF 4.654), 2020, Vol.477 (3), pp.747-762波特兰出版社
摘要:CGA-N12, an antifungal peptide derived from chromogranin A, has specific antagonistic activity against Candida spp., especially against Candida tropicalis , by inducing cell apoptosis. However, the effect of CGA-N12 on the Candida cell wall is unknown. The Candida protein KR...
作者:Aaron M. Collier , Yuliya Nemtsova , Narendra Kuber ...
来源:[J].Biochemical Journal(IF 4.654), 2020, Vol.477 (3), pp.727-745波特兰出版社
摘要:Late-infantile neuronal ceroid lipofuscinosis (LINCL) is a neurodegenerative lysosomal storage disorder caused by mutations in the gene encoding the protease tripeptidyl-peptidase 1 (TPP1). Progression of LINCL can be slowed or halted by enzyme replacement therapy, where rec...
作者:Anna Roesler , Lawrence Kazak
来源:[J].Biochemical Journal(IF 4.654), 2020, Vol.477 (3), pp.709-725波特兰出版社
摘要:Obesity results from energy imbalance, when energy intake exceeds energy expenditure. Brown adipose tissue (BAT) drives non-shivering thermogenesis which represents a powerful mechanism of enhancing the energy expenditure side of the energy balance equation. The best understood t...
作者:Henry M. Sanders , Blagojce Jovcevski , John A. Carver ...
来源:[J].Biochemical Journal(IF 4.654), 2020, Vol.477 (3), pp.629-643波特兰出版社
摘要:Deficits in protein homeostasis (proteostasis) are typified by the partial unfolding or misfolding of native proteins leading to amorphous or fibrillar aggregation, events that have been closely associated with diseases including Alzheimer's and Parkinson's diseases. Molecul...
作者:Sean Brennan , Hussein N. Rubaiy , Saba Imanzadeh ...
来源:[J].Biochemical Journal(IF 4.654), 2020, Vol.477 (3), pp.671-689波特兰出版社
摘要:ATP-sensitive potassium (KATP) channels are widely expressed and play key roles in many tissues by coupling metabolic state to membrane excitability. The SUR subunits confer drug and enhanced nucleotide sensitivity to the pore-forming Kir6 subunit, and so information t...
作者:Fatima Kamal Zaidi , Shashank Deep
来源:[J].Biochemical Journal(IF 4.654), 2020, Vol.477 (3), pp.645-670波特兰出版社
摘要:The aggregation of the protein alpha synuclein (α-Syn), a known contributor in Parkinson's disease (PD) pathogenesis is triggered by transition metal ions through occupational exposure and disrupted metal ion homeostasis. Naturally occurring small molecules such as polypheno...
作者:Feng-Juan Yan , Xu Wang , Song-En Wang ...
来源:[J].Biochemical Journal(IF 4.654), 2020, Vol.477 (3), pp.691-708波特兰出版社
摘要:Nonalcoholic fatty liver disease (NAFLD) is an expanding health problem worldwide. Although many studies have made great efforts to elucidate the pathogenesis of NAFLD, the molecular basis remains poorly understood. Here, we showed that hepatic C7ORF41, a critical regulator ...
作者:Armelle Vigouroux , Jeanne Doré , Loïc Marty ...
来源:[J].Biochemical Journal(IF 4.654), 2020, Vol.477 (3), pp.615-628波特兰出版社
摘要:Agrobacterium tumefaciens pathogens use specific compounds denoted opines as nutrients in their plant tumor niche. These opines are produced by the host plant cells genetically modified by agrobacteria. They are imported into bacteria via solute-binding proteins (SBPs) in as...
作者:Beibei Zhang , Natasha M. Nesbitt , Pedro José Barbosa Pereira ...
来源:[J].Biochemical Journal(IF 4.654), 2020, Vol.477 (3), pp.601-614波特兰出版社
摘要:The pro-oxidant effect of free heme (Fe2+-protoporphyrin IX) is neutralized by phylogenetically-conserved heme oxygenases (HMOX) that generate carbon monoxide, free ferrous iron, and biliverdin (BV) tetrapyrrole(s), with downstream BV reduction by non-redundant NADPH-depende...
作者:Elizabeth A. Rondini , James G. Granneman
来源:[J].Biochemical Journal(IF 4.654), 2020, Vol.477 (3), pp.583-600波特兰出版社
摘要:A central function of adipose tissue is in the management of systemic energy homeostasis that is achieved through the co-ordinated regulation of energy storage and mobilization, adipokine release, and immune functions. With the dramatic increase in the prevalence of obesity and o...

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