波特兰出版社
期刊
会议
图书
作者:Boris Krichel , Sven Falke , Rolf Hilgenfeld ...
来源:[J].Biochemical Journal(IF 4.654), 2020, Vol.477 (5), pp.1009-1019
摘要:Severe acute respiratory syndrome coronavirus is the causative agent of a respiratory disease with a high case fatality rate. During the formation of the coronaviral replication/transcription complex, essential steps include processing of the conserved polyprotein nsp7–10 re...
作者:Lina He , Yang Li , Ni Zeng ...
来源:[J].Biochemical Journal(IF 4.654), 2020, Vol.477 (5), pp.1021-1031
摘要:Hepatic glucose metabolism signaling downstream of insulin can diverge to multiple pathways including AKT. Genetic studies suggest that AKT is necessary for insulin to suppress gluconeogenesis. To specifically address the role of AKT2, the dominant liver isoform of AKT in th...
作者:Maicol Mancini , Laura Papon , Alain Mangé ...
来源:[J].Biochemical Journal(IF 4.654), 2020, Vol.477 (5), pp.1033-1047
摘要:Hepatocellular carcinoma (HCC) is the most frequent primary liver cancer in adults. Among the altered pathways leading to HCC, an increasing role is attributed to abnormal epigenetic regulation. Members of the Heterochromatin Protein (HP1) 1 family are key players in chromat...
作者:Alexander Yang , Emilio P. Mottillo
来源:[J].Biochemical Journal(IF 4.654), 2020, Vol.477 (5), pp.985-1008
摘要:Fatty acids (FAs) are stored safely in the form of triacylglycerol (TAG) in lipid droplet (LD) organelles by professional storage cells called adipocytes. These lipids are mobilized during adipocyte lipolysis, the fundamental process of hydrolyzing TAG to FAs for internal or...
作者:Noe Baruch-Torres , Junpei Yamamoto , Víctor Juárez-Quintero ...
来源:[J].Biochemical Journal(IF 4.654), 2020, Vol.477 (5), pp.1049-1059
摘要:Plant organelles cope with endogenous DNA damaging agents, byproducts of respiration and photosynthesis, and exogenous agents like ultraviolet light. Plant organellar DNA polymerases (DNAPs) are not phylogenetically related to yeast and metazoan DNAPs and they harbor three insert...
作者:Yugesh Kharel , Tao Huang , Anita Salamon ...
来源:[J].Biochemical Journal(IF 4.654), 2020, Vol.477 (5), pp.925-935
摘要:The interplay of sphingosine 1-phosphate (S1P) synthetic and degradative enzymes as well as S1P exporters creates concentration gradients that are a fundamental to S1P biology. Extracellular S1P levels, such as in blood and lymph, are high relative to cellular S1P. The blood...
作者:Vandna Sharma , Shekhar Kumar , Girish Sahni
来源:[J].Biochemical Journal(IF 4.654), 2020, Vol.477 (5), pp.953-970
摘要:To understand the role of substrate plasminogen kringles in its differential catalytic processing by the streptokinase — human plasmin (SK-HPN) activator enzyme, Fluorescence Resonance Energy Transfer (FRET) model was generated between the donor labeled activator enzyme and ...
作者:Hala Ouzon-Shubeita , Caroline K. Vilas , Seongmin Lee
来源:[J].Biochemical Journal(IF 4.654), 2020, Vol.477 (5), pp.937-951
摘要:The cisplatin-1,2-d(GpG) (Pt-GG) intrastrand cross-link is the predominant DNA lesion generated by cisplatin. Cisplatin has been shown to predominantly induce G to T mutations and Pt-GG permits significant misincorporation of dATP by human DNA polymerase β (polβ). In agreeme...
作者:Prakash Kalwani , Devashish Rath , Anand Ballal
来源:[J].Biochemical Journal(IF 4.654), 2020, Vol.477 (5), pp.971-983
摘要:The cyanobacterium Anabaena PCC 7120 shows the presence of Type I-D CRISPR system that can potentially confer adaptive immunity. The Cas7 protein (Alr1562), which forms the backbone of the type I-D surveillance complex, was characterized from Anabaena . Alr1562, showed the presen...
作者:Si-Jia Xue , Guang-Lei Liu , Zhe Chi ...
来源:[J].Biochemical Journal(IF 4.654), 2020, Vol.477 (5), pp.887-903
摘要:So far, it has been still unknown how liamocins are biosynthesized, regulated, transported and secreted. In this study, a highly reducing polyketide synthase (HR-PKS), a mannitol-1-phosphate dehydrogenase (MPDH), a mannitol dehydrogenase (MtDH), an arabitol dehydrogenase (Ar...

我们正在为您处理中,这可能需要一些时间,请稍等。

资源合作:cnki.scholar@cnki.net, +86-10-82896619   意见反馈:scholar@cnki.net

×