Hindawi期刊
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作者:Kun Song , Jingduo Hao , Zuyin Ge ...
来源:[J].Journal of Oncology, 2020, Vol.2020
摘要:Transcription factor sex-determining region Y-box 2 (SOX2) involves in the maintenance of cancer stem cells. However, the role of SOX2 in colorectal cancer (CRC) remains unclear. This study was conducted to investigate the effect of SOX2 on CRC. Studies were searched using e...
作者:Zhi-Gang Gao , Yong Yang , Xiao-Feng Han ...
来源:[J].Journal of Oncology, 2020, Vol.2020
摘要:Colorectal cancer (CRC) is the 5th leading cancer in China. Alcohol consumption has been reported to be one of the risk factors of CRC. However, it remains unclear whether genetic variants of alcohol metabolic genes are associated with CRC risk. In this study, we tested the ...
作者:Wentao Zhou , Yuan Fang , Xu Han ...
来源:[J].Journal of Oncology, 2020, Vol.2020
摘要:Backgrounds . Pancreatic neuroendocrine neoplasm (pNEN) is a highly heterogeneous entity, presenting widely varied biological behavior as well as long-term prognosis. Reliable biomarkers are urgently needed to make risk stratifications for pNEN patients, which could be benef...
作者:Brianna Lauren , Sassan Ostvar , Elisabeth Silver ...
来源:[J].Journal of Oncology, 2020, Vol.2020
摘要:Background . The 5-year survival rate of patients with metastatic gastric cancer (GC) is only 5%. However, trials have demonstrated promising antitumor activity for targeted therapies/immunotherapies among chemorefractory metastatic GC patients. Pembrolizumab has shown particular...
作者:Kun Huang , Ningning Gao , Donglin Bian ...
来源:[J].Journal of Oncology, 2020, Vol.2020
摘要:Epithelial-mesenchymal transition (EMT) plays an important role in the invasion and metastasis of colorectal cancer, which is mediated by FAK and EGF. However, whether FAK participates in EMT in colorectal cancer cells through the EGF/EGFR signaling pathway remains unknown. ...
作者:Shu-Man Li , Jie Zhou , Yun Wang ...
来源:[J].Journal of Oncology, 2020, Vol.2020
摘要:Immune checkpoint therapy, such as the reactivation of T-cell activity by targeting programmed cell death 1 (PD-1) and its ligand PD-L1 (also called B7-H1 and CD274) has been found pivotal in changing the historically dim prognoses of malignant tumors by causing durable objective...
作者:Su Jin Lee , Jung Yong Hong , Kyung Kim ...
来源:[J].Journal of Oncology, 2020, Vol.2020
摘要:Successful identification and targeting of oncogenic gene fusion is a major breakthrough in cancer treatment. Here, we investigate the therapeutic implications and feasibility of using a targeted RNA sequencing panel to identify fusion genes in gastrointestinal and rare canc...
作者:F. Pellini , S. Mirandola , E. Granuzzo ...
来源:[J].Journal of Oncology, 2020, Vol.2020
摘要:Introduction . Male breast cancer (MBC) is a rare disease, whose main risk factor is genetic vulnerability. Despite care of men with MBC is modeled on care of women, men’s experiences with the disease and concerns related to the status of genetic mutation carrier are unique....
作者:Ayako Nakashoji , Tetsu Hayashida , Yuko Kawai ...
来源:[J].Journal of Oncology, 2020, Vol.2020
摘要:First identified as a developmental gene, HOXB9 is also known to be involved in tumor biological processes, and its aberrant expression correlates with poor prognosis of various cancers. In this study, we isolated a homeodomain-less, novel HOXB9 variant ( HOXB9v ) from human brea...
作者:Hikmat Abdel-Razeq , Luna Zaru , Ahmed Badheeb ...
来源:[J].Journal of Oncology, 2020, Vol.2020
摘要:Background and Objectives . Breast cancer has been the most common cancer affecting women in Jordan. In the process of implementing breast cancer prevention and early detection programs, individualized risk assessment can add to the cost-effectiveness of such interventions. ...

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